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Q: My husband and I have been advised to have preimplantation genetic diagnosis (PGD) before undergoing IVF. But I’m afraid. Can’t it cause my baby to have birth defects?
A: Although concerns have been raised regarding PGD and birth defects, one recent study of 583 births at one center found that the rate of birth defects, 3.6 percent, was no higher than among infants born after IVF who did not undergo PGD.

Before undergoing PGD, you may want to learn more about the procedure. Ask your fertility center’s embryologist for more information and also speak to your doctor. It’s important to feel comfortable before agreeing to any procedure.

Date Posted: August 7, 2007
Q: I’m pregnant and having a baby boy. I just heard that it’s not good to eat beef. Is this true?
A: According to a recent study conducted by researchers at the Center for Reproductive Epidemiology, it’s best to limit your intake. Pregnant women who consumed seven or more servings of beef per week had sons with 24 percent below normal sperm counts. They were also three times more likely to develop fertility problems than males born to women who didn’t consume as much beef while pregnant.

The researchers believe that the problem may be due to anabolic steroids used in the U.S. to fatten cattle. Pesticides and other environmental contaminants also may contribute.

Six growth-promoting hormones are regularly used in Canadian and U.S. cattle production. They are: the natural steroids estradiol, testosterone, and progesterone, and the synthetic hormones zeranol, trenbolone acetate, and melengestrol acetate. When the cattle are killed, not all of these hormones have been metabolized.

Also used in U.S. cattle production between 1954 and 1979 was diethyl stilbestrol (DES), a synthetic hormone. It was banned after tests indicated that minks fed chicken waste containing DES became infertile.

European countries banned all of the hormones mentioned above in beef in 1988. There has been heated dialogue ever since of banning imports of U.S. beef containing hormones.

The study results are part of a growing body of research linking maternal health and habits to their children’s long-term health. This new field of inquiry, known as the developmental origins of health and disease, hopes to ensure the health of women of reproductive age so that their children can enjoy lives free of debilitating diseases that may be mostly preventable with better prenatal care.

Date Posted: August 8, 2007
Q: I am quite a snorer. Will this have any effect on my baby? I’m due later this year.
A: According to recent research even mild sleep disorders such as yours can affect fetal outcomes during pregnancy. Dr. Susan M. Harding, a professor of medicine at the University of Alabama, Birmingham, and medical director of the Sleep/Wake Disorders Center in Birmingham, presented these findings at a sleep medicine meeting sponsored by the American College of Chest Physicians. According to a Swedish study, 14 percent of women who snore are hypertensive, while only 6 percent of those who don’t snore have high blood pressure.

Preeclampsia(pregnancy-induced hypertension) also was more prevalent in women who snore (10 percent) versus only 4 percent of those who don’t snore.

Moreover, studies indicate that this sleep disorder tends to be passed on to future generations. Habitual snoring is an independent predictor of hypertension and growth retardation in snorers’ babies. According to Dr. Harding their infants were significantly more likely to score 7 or lower on the Apgar scale 1 minute after birth and to be small for their gestational age.

Date Posted: April 30, 2007
Q: Is it safe for a pregnant woman to take pain relievers?
A: Ibuprofen (Advil®, Motrin®, Nuprin®), and naproxen (Aleve), both in the class of nonsteroidal anti-inflammatory drugs (NSAIDs), are not recommended. They may increase miscarriage risk early on and can harm the fetus’ developing heart or kidneys. Before taking any pain reliever while pregnant, please consult with your obstetrician.

Date Posted: December 11, 2006
Q: I just learned that I have fibroids, and I want to try a new ultrasound technique to remove them. Is it safe for women trying to get pregnant?
A: No, it’s not. The U.S. Food and Drug Administration (USDA) recently approved the ExAblate 2000, a device that aims concentrated ultrasound airwaves through the skin to burn away fibroids. The procedure is practically painless, but it can cause cramping. It’s also not recommended for women who want to conceive.

Talk to your physician. There are other safe ways to treat fibroids that will not compromise your fertility. Fibroids are the benign yet often painful uterine tumors suffered by as many as 40 percent of women over age 35. Date Posted: December 11, 2006
Q: My husband’s family is all overweight. I recently heard that eating soy during pregnancy can prevent obesity in my child as an adult. Is this true?
A: A new study from Duke University Medical Center published in the journal Environmental Health Perspectives found that when pregnant mice consumed ample amounts of genistein, a nutrient found in soy, their offspring weighed less as adults. Mice whose mothers did not eat genistein while pregnant were twice the weight as adults as their soy-fed peers. “We are increasingly finding that our parents and even our grandparents’ nutritional status and environmental exposures can regulate our future risk of disease,” Randy Jirtle, professor of radiation oncology and senior author of the study told The New York Times. Although the effect has not been studied in humans, Jirtle believes that the impact of feeding infants soy milk should be assessed for its obesity prevention benefit later in life.
Q: Are artificial sweeteners safe during pregnancy?
A: The jury is still out on the answer to this question, but avoiding them is probably best according to Janet Starr Hull, Ph.D., a nutritionist and author of "Splenda: Is it Safe or Not?"(Pickle Press: 2005). Splenda® (sucralose) and Equal® (aspartame) have not been found to harm the fetus, but they are still chemicals and cross the placenta. Sweet‘n Low® (saccharin) has been found to be especially harmful since the fetus metabolizes it slowly, and neonatal exposure to it has been linked to increased cancer risk.

It’s best to consume healthy, nutritious foods when pregnant. For a low-calorie alternative to diet sodas, sip on water with a wedge of lime or lemon. For more information on how to eat healthy during pregnancy, please click on the Stork’s Nutrition Program link under Nutrition on this website.
Q: My doctor wants me to take extra folate while I’m pregnant, but I heard that it can cause breast cancer. What should I do?
A: You should continue to take the added folate. Folate has been repeatedly shown to prevent neural tube defects in unborn children. While it’s true that a British study found an increased risk of death from breast cancer among a group of women who had taken folate decades ago while pregnant, the study was flawed. Not only did the women in the study take five times as much folate as doctors today recommend, but also the study was so small that its results could be attributable to chance. Other research has found that folate may in fact decrease the risk of breast cancer, as well as colon cancer and heart disease.
Q: My husband and I are trying to conceive. I know that smoking can affect a man’s sperm. Can chewing tobacco also affect it?
A: Yes, it can. Researchers from the Cleveland Clinic in the U.S. and the Karthekeya Center in India found that men who chew tobacco do not have as healthy sperm as those who do not take part in the activity. The damage to the sperm increases with the frequency of tobacco chewing.

The researchers examined semen quality reports from more than 600 men in India who were undergoing infertility evaluations. They measured the frequency of their tobacco chewing and evaluated sperm quality, motility (movement), morphology (shape) and viability. They found that men who chew tobacco only “moderately” had largely normal sperm parameters. However, those who used tobacco more frequently were more likely to have poorer-performing sperm. Their findings were published in the journal Fertility & Sterility.
Q: I have type 2 diabetes and am trying to get it under control so that I can conceive. I recently heard that coffee can help lower blood pressure and help control type 2 diabetes. Is this true?
A: Because it’s plant-derived, coffee contains many of the same beneficial compounds as those found in vegetables, including antioxidants, according to recent research conducted by Jane Shearer, Ph.D., a biochemist at the University of Calgary.

Scientists at Piedmont Hospital in Atlanta reported that it’s not regular coffee but decaf that increases LDL cholesterol, raising the risk of heart disease. The Nurse’s Health Study found that heavy coffee drinkers had lower rates of hypertension, indicating that coffee might be protective. Compared with those who don’t drink java, coffee drinkers have lower risks for liver disease, type 2 diabetes, and some types of ovarian cancer.

Ask your doctor what’s best for you. Most experts still advise limiting coffee intake to two to three cups daily.
Q: I am trying to conceive and need to lose weight, but I find myself eating more during the winter months. Why is this so?
A: “Some people tend to overeat during the winter months because it gets dark earlier, and they feel cooped up and eat out of boredom or habit, “ says Andrea Silverstein, RD, a medical nutrition therapist with DVIF&G.; “Many people actually suffer from a form of depression called “winter blues” from the fall through the spring that brings on feelings of irritability that leads to increased eating.”

This problem is discussed in a recent article called “Munching Out of Winter Blues” by Elizabeth Somer, MA, RD, published on the WebMD.com website. In the article Ms. Somer points out that the reasons for mood changes vary but may be caused by a drop in serotonin, a brain chemical that regulates mood and hunger. She writes: “In response to low serotonin levels, your body craves sweets which can raise serotonin levels, making you feel better – temporarily. That serotonin high is usually followed by a crash, setting up a hunger and mood roller coaster that can lead to overeating and weight gain.”

To deal with this challenging problem, it is recommended to eat whole grain/high quality carbohydrates instead of sweets such as whole-grain breads, crackers, pretzels, popcorn, figs, corn, or potatoes. Portion sizes of these foods need to be kept in check if blood sugars are an issue and also because they can still pack on the calories! Another solution is to try cutting back on the carbohydrate choice and adding some protein to the mix (i.e. turkey, tuna, chicken, egg, cheese, peanut butter, or milk).

The article also discussed that mood changes can be caused by a more extreme form of depression known as Seasonal Affective Disorder (SAD) that may require medical intervention. Researchers have found that eating foods rich in vitamin B, such as chicken, kidney or black beans, lentils or split peas, fish, bananas, avocados, and dark-green leafy vegetables may help. Researchers at the University of Arizona Health Science Center at Tucson found that one in four patients with depression were deficient in vitamins B2, B6, B12, and folic acid. Other mood boosters include low-impact exercise, such as walking, swimming, or yoga, and a dose of natural or specially designed full-spectrum, artificial sunlight.

Eat right, stay active, and discuss any concerns with your physician—because winter will be back next year.
Q: I’ve had three miscarriages in a row and desperately want to conceive. A friend of mine says that this is known as early pregnancy loss, a type of infertility. How can this be called infertility when I am able to conceive a child but can’t carry it to term?
A: As many as 15 percent of clinically recognized pregnancies end in miscarriage between the 4th and 20th week of gestation. Recurrent pregnancy loss (RPL) is usually defined as three consecutive losses, but most couples will seek medical help after the first or second loss. Tests are available to evaluate the more common causes of RPL but, unfortunately, in more than half of the cases no definitive cause for the losses can be found.

Chromosomal abnormalities are found in 50 to 85 percent of spontaneous miscarriages. Most of theses involve either the addition or loss of an entire chromosome. Balanced translocations are the most common inherited chromosomal abnormality, occurring in about 2 to 4 percent of couples experiencing RPL. A balanced translocation occurs when parts of one chromosome are incorporated into a different chromosome.

Uterine abnormalities, such as a uterine septum or uterine adhesions have been linked to RPL. Unicornuate, Bicornuate, and Didelphys are not associated with early pregnancy loss. They are only associated with pregnancy loss after the first trimester.

Hormone/metabolic disorders that have been associated with RPL include luteal phase defect and polycystic ovarian syndrome (PCOS). The luteal phase defect may result in a disrupted endometrial lining. This can lead to problems with the embryo properly implanting itself in the uterus. In PCOS, the elevated LH and/or elevated testosterone levels may be responsible for RPL.

Well-controlled diabetes and thyroid disease are not associated with RPL. Autoimmune disorders such as Systemic Lupus Erythematosus are associated with loss in the second and third trimester but not with early pregnancy loss.

Unfortunately, no explanation for recurrent pregnancy loss is found in more than 50 percent of couples.

No matter what the cause of early pregnancy loss, the good news is that the majority of couples with RPL go on to achieve successful pregnancies. Here at DVIF&G;, we have a special Early Pregnancy Loss program to help patient cope with the condition and to treat it. David R. Corley, M.D., FACOG, is the director of the program. To make an appointment with him, please call (856) 988-0072.
Q: My sister is in her first trimester of pregnancy and has hyperemesis gravidarum. What is this condition and is it serious?
A: Hyperemesis gravidarum is an exaggerated form of morning sickness that occurs in approximately fewer than 1 in 200 pregnancies. This excessive vomiting of pregnancy is more common in first-time mothers, in women who are carrying multiple fetuses, and in women who experienced it during a previous pregnancy. Psychological stress may be a factor, as well as the sensitivity of the vomiting center in the brain which seems to vary from person to person.

Women with hyperemesis gravidarum may experience this form of morning sickness throughout their pregnancy, instead of just the first trimester which is usually the case. If untreated, the frequent vomiting can lead to malnutrition, dehydration, and possibly harm to the health of the mother or baby.

For milder cases, treatment may involve dietary measures, rest, antacids, and antiemetic (anti-vomiting) medication. If vomiting continues and not enough weight is being gained, however, hospitalization may be required. Further tests may be conducted to rule out nonpregnancy-related causes of vomiting, such as gastritis, an intestinal blockage, or an ulcer. If necessary, intravenous feeding may be given, along with an antiemetic.
Q: I heard that dark chocolate can help me better manage my diabetes. Is this true?
A: According to a recent study published in the American Journal of Clinical Nutrition dark chocolate may improve insulin sensitivity and resistance and lower blood pressure. Researchers at the University of L’Aquila in Italy found that the flavanols found in dark chocolate but not in white chocolate may exert a protective action on vascular health by improving insulin sensitivity. But don’t run out today and start eating loads of chocolate. The researchers plan to continue their research in studies with larger groups and in groups with diabetic and hypertensive people to confirm their findings. A diet rich in fresh fruit and vegetables and low in fat and processed foods combined with regular cardiovascular exercise has already been proven to lower a person’s blood pressure and to prevent diabetes and other chronic diseases.
Q: My husband and I are trying to conceive, and we desperately want a girl. I recently read an article on sperm separation that claimed the process can guarantee a certain sex. Does it work and is it safe?
A: At this time the new technique that you mention called MicroSort® is not yet available to the public. A clinical trial is underway to determine its safety and efficacy. The trial is being conducted by the Genetics & IVF Institute (GIVF) in Fairfax, Virginia. GIVF also holds the license for MicroSort®. How the new technique works is by sorting sperm into batches containing mostly X chromosomes (for a girl) and mostly Y chromosomes (for a boy) that can then be used for fertilization. At this time, MicroSort® only claims an average of 88 percent X-bearing sperm in the sorted specimen and an average of 73 percent Y-bearing sperm in the sorted specimen. For more information on MicroSort®, visit www.microsort@givf.com.
Q: Is there a genetic link to preeclampsia? My sister had it while she was pregnant, and I’m afraid to conceive due to that fact.
A: Preeclampsia (high blood pressure during pregnancy) is difficult to predict and not all that common. It tends to happen to first-time, over age 35, and overweight mothers. There is no genetic link. To guard against developing preeclampsia, women should gain the recommended amount of weight, eat right, and see their obstetrician regularly for careful monitoring. There’s also a new urine test on the horizon that will be able to predict who is most likely to develop preeclampsia.
Q: My next-door neighbor just had a prenatal portrait done, but I’ve heard that this type of procedure can be dangerous to the fetus. Is this 3-D ultrasound scan safe?
A: You’re right to be concerned. Although there’s no clinical evidence that these 3-D “keepsake” ultrasound scans will harm a fetus, the Food and Drug Administration and American College of Obstetricians and Gynecologists are against them. These professional organizations fear that ultrasound’s heat and vibration could damage tissue if administered by someone who doesn’t have medical training. Apparently some practitioners who perform keepsake ultrasound in nontraditional medical settings such as health centers at strip malls may have no more than a weekend’s worth of training.

The procedure’s length is a concern also. A fetus can be subjected to as much as an hour of imaging, plus repeat visits.

To receive the best prenatal care possible, stick with a trained sonographer at a reputable medical practice. The images of your baby may be of the grainy, black-and-white kind, but you won’t have to worry about your fetus’ safety. There will be plenty of opportunity for great 3-D after your child is born.
Q: I have a heart condition and desperately want to conceive a child. How does heart disease affect pregnancy?
A: The most common heart complication in pregnancy is heart valve abnormalities. A condition called mitral stenosis can be very dangerous, even life-threatening, during pregnancy. Heart failure with fluid build-up in the lungs may occur, and abnormal heart rhythms may develop. Mitral stenosis is a narrowing of the mitral valve, resulting in a decrease in blood flow within the heart. If you have mitral stenosis, you should be evaluated by a cardiologist before getting pregnant.

The good news is that if you have other heart valve problems, such as mitral valve prolapse, they tend to be well-tolerated during pregnancy.
Q: About a year ago I learned that I have Type 2 diabetes and also that I have polycystic ovarian syndrome (PCOS). I desperately want to have a baby and have lost 30 pounds by exercising daily and eating right. I also took medication to help my diabetes, but now I no longer have to take it. My doctor tells me that I now have these conditions under control. Does this mean that I am no longer diabetic?
A: Once you are diagnosed as a diabetic, you are still considered a diabetic by medical history even if the condition is controlled by diet and exercise and blood sugar levels are normal.

The major difference between you and a nondiabetic is that if you gain weight, your blood sugars will rise and you will probably have to go back on medication to control your insulin resistance. The nondiabetic will just become obese and at risk for developing diabetes.

Congratulations on your progress. Many women successfully keep diabetes under control and go on to give birth to healthy children.
Q: I’m a carrier of hepatitis B and just found out that I’m pregnant. Will my being a carrier hurt my baby?
A:

The fact that you know you’re a carrier for hepatitis B is the first step in ensuring that the condition will not harm your baby. Although some children born to some carriers (those with a certain antigen) are at high risk for infection, treating them within 12 hours of birth with hepatitis B vaccine and immune globulin can almost always prevent such an infection.

Be sure to tell your obstetrician that you’re a carrier so that a titer is taken to determine how contagious you are and that your baby is treated as needed. Treatment is repeated at 1 and 6 months, and the child is usually tested at 12 to 15 months to be sure that the treatment has been effective.

Q: I have difficulty sleeping and am currently being treated at a sleep disorders clinic in my area. Is it true that not enough shut-eye can affect fertility?
A:

Yes it can. Over the past decade more and more studies have shown a link between sleep deprivation and a host of health problems, including obesity, depression, and infertility. Since the immune system is weakened when a person doesn’t get the sleep he or she needs, the body doesn’t work at its full capacity. This makes conception difficult.

South Australian scientists at the University of Adelaide also have recently discovered that “clock genes” that manage daily body rhythms may play a more important role in fertility than previously believed.

In their study of mice, they found that those without a gene that regulated body rhythms were “profoundly infertile.” In an article in the January 2005 issues of the journal Human Reproduction Update, they explain their theory of disrupted circadian rhythms in reproduction.

They plan to conduct further research into the behavior of clock genes and their interaction with the environment to find answers to some of infertility’s most puzzling questions, including why only some embryos grow in the laboratory and why some couples with no known reproductive problem cannot conceive.

Q: I’m looking to have an IVF procedure done. Is there a limit as to how many embryos I can have transferred?
A:

The American Association for Reproductive Medicine (ASRM) and SART Practice Committee recently published new guidelines to aid assisted reproductive technologies (ART) programs and their patients. The new guidelines will help to minimize the incidence of multiple pregnancies that carry risks both to the mother and to the children.

The committee recommends that under ordinary circumstances, patients under age 35 should have no more than two cleavage-stage embryos be transferred. Older patients may have more than two transferred, but the number will be determined by the prognosis criteria.

Q: I just heard that laptop computer use could harm a man’s fertility. Is this true? I’m worried because my husband uses one every day, and we want to start a family soon.
A:

At this point in time you don’t have anything to worry about. Urologists at the State University of New York at Stony Brook conducted the small study to which you refer. Although they found that long-term use of laptops could reduce sperm formation by raising temperatures in the genital area, more studies need to be conducted to determine whether these side effects are short-term or long-term.

The researchers found that keeping a laptop on the lap for an hour can raise scrotal temperatures by more than 2.5 degrees Celsius, enough to affect fertility significantly, according to a report published in the December 9th issue of the European journal Human Reproduction.

The best way to safeguard a man’s fertility while using a laptop is to put it on a desk instead of on the lap, say the researchers.

Q: I’m on a low-carb diet and am also trying to get pregnant. Are there any risks I should know about if I stay on this diet?
A:

Yes there are, especially if you have cut back on cereals, crackers, and other foods made with grain fortified with folic acid. According to an article published by Dr. Gideon Koren, professor of Pediatrics, Pharmacology, Pharmacy Medicine, and Medical Genetics at the University of Toronto, with an estimated 10 to 15 percent of American and Canadian women on low-carb diets, a growing number of women are not eating enough folic acid from flour products to prevent neuro tube defects in their offspring.

According to the article before flour and other products were fortified with folic acid, the typical woman consumed slightly less than 200 mg of folic acid from dietary sources alone. This is far less than the daily-recommended 400 mg of folic acid per day for women of childbearing age.

Anyone who is trying to conceive, including those on low-carb diets, should take prenatal vitamins. Remember, as many as half of all pregnancies are unplanned which generally means that women may not know that they’re pregnant until four to six weeks of gestation. Unfortunately the fetus’ neuro tube has already closed by this time if the mother had not been getting her needed supply of folic acid.

Q: I’m trying to lose weight and lower stress to increase my chances of conceiving. My problem is that I don’t like to exercise. I’ve heard that tai chi is a good low impact way to exercise. Do you think it’s a good choice for me?
A:

Congratulations on deciding to make proper lifestyle changes to be the healthiest you can be when you conceive. Regular exercise has been proven to relieve stress. It also can help protect the cardiovascular and immune systems from the consequences of stressful events.

Tai chi is a good choice for someone who wants low impact exercise. The health advantage of this ancient Chinese system of physicial exercises lies in its breathing method and slow movements. These series of fluid motions are circular, slow, and together form one, larger posture. The deep breathing helps to relieve stress, while the coordination of upper-body moves with the shifting of weight from leg to leg promotes total fitness. Tai chi also has been found to improve flexibility, muscular stamina, and strength. Before beginning any new exercise regime, however, it’s important to consult with your physician.

Q: I’m taking raspberry leaf and ginger, as well as some other herbs to help with morning sickness. Are they safe?
A:

No, they’re not, according to a recent article published in the August 2004 issue of OB/GYN News. “Many herbal preparations taken during pregnancy are innocuous, but some are ineffective and others are downright dangerous,” Dr. Tieraoana Low Dog of the University of New Mexico in Albuquerque told his colleagues at a meeting on botanical medicine sponsored by Columbia University and the University of Arizona.

Raspberry leaf, often taken to alleviate morning sickness, prevent miscarriage, and aid in childbirth, was found to be safe. A randomized controlled study of 192 women found that women who used raspberry tea from week 32 to delivery had no adverse affects. However, the herb had no perceptible effect on the timing of labor, the length of labor or the need for analgesia.

Ginger also is often taken to alleviate morning sickness. Three clinical trials have confirmed some benefit in this regard without finding harmful effects to the mother or infant. However Dr. Dog told the group, “to be on the safe side, women should limit ginger consumption to one gram per day.” In excessive doses, ginger may affect bleeding tendencies. One study that involved patients taking 10 grams of ginger was associated with significant reduction in agonist induced platelet aggregation.

The British Herbal Medicine Association considers chamomile, which is often ingested in tea made from its flower, safe for consumption during pregnancy. There have been no reports of adverse affects.

Blue cohosh, which is used to stimulate labor, should be wholly avoided in pregnancy, according to the University of New Mexico researchers. Often combined with black cohosh and taken as a uterine tonic or partus preparation during the last six weeks of pregnancy, blue cohosh has been used for these purposes since the 19th century. It is still widely prescribed by lay midwives. In one survey 52 percent of certified nurse midwives said that they recommended labor-stimulating preparations. Of these, 64 percent used blue cohosh and 45 percent used black cohosh. Complications, which were reported by 21 percent of the respondents who used either blue or black cohosh, included transient fetal tachycardia, meconium stained fluid, and nausea.

Q: Can menopause be predicted?
A:

A study appearing in the June 2004 issue of the Journal of Human Reproduction suggests that it can. The researchers believe that since ultrasound can be used to measure the volume of the ovary, this volume may be able to predict when menopause will set in and how many fertile years a woman has left.

It has long been known that the number of eggs in the female ovary peaks at several million while she is still in the womb about halfway through gestation. From this point on, she experiences a continuous decline in the total number of eggs. At birth approximately one to two million eggs remain. The amount decreases to about 300,000 at the time menstruation begins. At around age 37 a woman has about 25,000 eggs left. In menopause she has only about 1,000 eggs left.

While these researchers have developed a tool to potentially help women plan their reproductive lives, a second study published in the Journal of Human Production warned that women might not want to wait too long before starting a family. Assisted reproductive technology (ART) cannot be relied upon to fully compensate for the lack of natural fertility after age 35. The authors used a computer simulation model to determine that the overall success rate of reproductive technology would be 30 percent for those trying to conceive at age 30, 24 percent at age 35, and 17 percent at age 40.

Even armed with such studies, patients should understand that it is at best difficult to predict at what point in their lives it will become too difficult to conceive.

Q: Besides infertility, what are the symptoms of PCOS?
A:

Symptoms of PCOS include: irregular menstrual cycles (few or no periods) excess facial or body hair acne sudden unexplained weight gain problems maintaining a healthy weight darkened patches of skin on the neck, groin, under the arms, or in the skin folds depression or anxiety elevated cholesterol, especially LDL, and/or triglycerides and a family history of diabetes or heart disease.

Q: I have chronic fatigue syndrome, and I really want to get pregnant. I’ve heard, however, that pregnancy can only worsen my condition. Is this true?
A:

According to a recent study conducted by Richard Schacterle, Ph.D., and Dr. Anthony Komaroff of Brigham Women’s Hospital in Boston, that’s usually not the case. They found that the symptoms of chronic fatigue syndrome usually do not worsen during pregnancy.

The study, which was published in the April 1, 2004 edition of OB/GYN News, involved 86 women with the condition who experienced a total of 256 pregnancies, some before and some after the onset of the syndrome. During pregnancy, 41 percent of the women reported no change in symptoms, 30 percent noted an improvement in symptoms, and 29 percent found that their symptoms worsened.

The investigators also found no significant difference in a host of maternal complications and outcomes when they compared pregnancies that occurred before the onset of chronic fatigue syndrome and those that occurred after the onset of the condition. The only exceptions were a higher rate of spontaneous abortions and a correspondingly lower rate of live births by vaginal delivery after the syndrome’s onset. These differences, however, could have been compounded by age or parity as stated by the researchers.

Before trying to conceive, you should consult with your physician.

Q: My husband and I are now visiting doctors about our infertility. Although I have had all of the preliminary tests done, my husband refuses to have a semen analysis done. What is a semen analysis and what is its purpose?
A:

To help your physicians determine why you and your husband have had trouble conceiving, a semen analysis is usually taken. The analysis is done the same day by a laboratory clinician. The sperm will be examined for a number of factors, including:

• the time for the semen to become liquid

• the semen’s volume, consistency, and pH (measure of its acidity).

• sperm count

• motility (percentage of moving sperm)

• morphology (normality of shape)

• agglutination (“clumping”) of sperm

• the presence of elements other than sperm, such as white blood cells or bacteria.

A normal ejaculate has more than 20 million sperm per ml. More than 40 percent of the sperm should be moving forward, and, using strict criteria, more than 14 percent should have normal shapes.

The sooner you both have the tests needed performed, the sooner you can get the treatment you need to conceive the baby you always wanted.

Q: My husband and I are going to start trying to conceive. He loves to soak in our hot tub and to sit in the steam room at our club. I told him he has to stop since it can hurt our chances of having baby. He thinks I’m paranoid. Is there any truth to too much heat hurting sperm or is it just a myth?
A:

It’s probably a good idea to have your husband give up his hot tub and steam room visits until after you have conceived. The testes are supposed to be five degrees lower than a man’s body temperature. The sperm can overheat if the testes’ temperature rises too high.

Q: My sister has had an eating disorder for over a year. Although she’s below normal weight (5 ft. 5 inches tall and 110 pounds), she thinks she’s fat and hardly eats anything at all. I think she’s anorexic. She and her husband have been trying to conceive, but I’m afraid that she won’t be able to conceive due to her problem. Can her problem affect her ability to have a child?
A:

Characterized by disrupted eating habits, unhealthy weight management practices, and distorted perceptions about weight and body shape, eating disorders affect 10 million girls and women in the U.S. The top three eating disorders, anorexia nervosa (selfinduced starvation), bulimia (bingeing and purging), and binge eating disorder (uncontrollable eating) are considered psychological problems, but they have serious health complications and may be life threatening.

Besides damaging the heart, kidneys, electrolye balance, and many bodily functions, eating disorders also can make conceiving and delivering a healthy baby difficult. Infertility often occurs in women with eating disorders because menstrual cycles and hormones are out of kilter. Because they’re not eating or drinking enough of the proper foods, malnutrition and vitamin deficiencies occur. This unhealthy nutritional balance increases the likelihood of high-risk pregnancies and miscarriage. If carried to full-term, the likelihood of birth defects, stillborn babies, and death of chronic illness in newborns rises. Women with eating disorders also are at high risk of developing polycystic ovarian syndrome, a condition that makes it difficult for a woman to conceive and also increases the rate of miscarriage if she does conceive.

If your sister is serious about wanting to have a healthy baby, then she needs to overcome her problem. She should make an appointment with her physician to be referred to a counselor that specializes in helping victims of eating disorders. Once she’s on the road to recovery, then she should visit a fertility specialist.

Q: I have hyperthyroidism and want to begin trying to conceive. I’m on a medication called PTU. Even though I’ve been told PTU is safe, I’m still concerned for my unborn child. Have there been any studies on being pregnant with hyperthyroidism and taking PTU?
A:

One of the most common hormonal disorders, hyperthyroidism is a condition where the thyroid gland becomes overactive and secretes too many thyroid hormones, especially the hormone thyroxine. Hyperthyroidism is more common in females and usually occurs between the ages of 20 and 50. About 75 percent of its cases are due to Graves’ disease, an autoimmune disorder in which the immune system produces antibodies that attack the thyroid gland, resulting in excessive secretion of thyroid hormones. Graves’ disease runs in families and may have a genetic basis.

People with vitiligo (a rare skin disorder) and pernicious anemia (a blood disorder) may also develop hyperthyroidism. Thyroid nodules that secrete too many hormones also can cause hyperthyroidism. Thyroiditis (inflammation of the thyroid gland) can cause symptoms of hyperthyroidism to occur temporarily.

Common symptoms of hyperthyroidism include weight loss, persistent tremor, and quick and sometimes irregular heartbeat. Drugs for hyperthyroidism reduce the activity of the thyroid gland. These antithyroid drugs are usually taken for 12 to 18 months until the thyroid gland can produce enough hormones on its own. The drug you are taking propylthiouracil (PTU) is one of the most common and effective antithyroid drugs available.

With expert medical care and guidance, the pregnant woman with hyperthyroidism has just about as good a chance of having a successful pregnancy and healthy baby as any other expectant mother does. Your physician will prescribe levels of the drug for pregnancy use only. The risks of taking the medicine, if any, are quite small compared to the benefits of keeping you well. If you still have to be on the medication after delivery, the levels prescribed may also change.

Q: I am a 28-year-old healthy woman considering starting a family. My mother has repeatedly reminded me that before my husband and I begin trying to conceive, I should have the chicken pox vaccination that I never received as a child. Is this true, and what are the possible consequences if I do not have it? Is it unwise to become pregnant without having this immunization?
A:

Answers to your questions depend upon whether or not you had the chicken pox as a child. If you did, then you do not have to get the chicken pox vaccine. However, if you did not get the chicken pox as a child, then you should consider being vaccinated. If you’re not sure, your physician will recommend a blood test to determine whether you’re immune. If you’re not immune and do not have protective antibodies from prior exposure to the virus, you will be given the varicella vaccine (against chicken pox). Couples are then advised to wait at least three months to try to conceive.

A woman who is already pregnant should not receive the vaccine. Besides causing more severe symptoms in adults than in children, chicken pox can cause problems in fetuses. One risk is congenital varicella syndrome, a group of birth defects that can include scars, muscle and bone defects, malformed and paralyzed limbs, a less than normal size head, blindness, seizures, and mental retardation. Congenital varicella syndrome affects only about 2 percent of babies who mothers developed chicken pox during the first 20 weeks of pregnancy. If a mother contracts chicken pox after 20 weeks of pregnancy, the syndrome is extremely rare.

Another risk occurs when the mother is infected with the virus from five days before to two days after delivery. Without preventive treatment, about one-quarter of newborns become infected with a severe chicken pox infection and develop a rash between five and 10 days after birth. According to the March of Dimes, up to 30 percent of infected babies die if not treated.

The good news is that these infections can usually be prevented or the accompanying symptoms greatly lessened if the newborn is treated immediately after birth with a VZIG (varicella-zoster immune globulin) injection. New antiviral drugs also are helpful in managing severe symptoms.

Q: Q: I am 40 pounds overweight. Is it true that obesity and infertility are linked?
A:

Infertility problems and weight go hand in hand. Research has found that obese women are two times more likely to be infertile than women of healthy weight. They also suffer from irregular menstrual cycles and weakened immune systems, making conception difficult. In addition, obesity can cause men to produce inferior sperm, another reason for infertility in couples.

Many times severely overweight people can develop a relatively common, though not well-known, condition called “Syndrome X. ” This condition is caused by having too much insulin in the body. “Syndrome X” can not only impede a woman’s ability to become pregnant but her ability to carry to term as well.

If you do conceive, being obese also can make your pregnancy more difficult. The risk of hypertension and diabetes in the form of preeclampsia and gestational diabetes rises, and delivery can be complicated because overweight mothers tend to deliver large babies. That’s why it’s so important to be at a healthy weight while trying to conceive.

DVIFG has a nutritionist and expert on Syndrome X on staff to help overweight patients lower their weight and insulin resistance to conceive the children they always wanted.

Q: I am a 28-year-old woman who smokes. I would like to have children. Can smoking affect fertility?
A:

Yes it can. Women who smoke have consistently been found to have decreased fertility. Researchers believe that smokers have higher rates of certain hormones that can lessen their chances of conceiving. Moreover, women who smoke are more likely to begin menopause at a younger age than average. Studies have also found that even during in vitro fertilization, eggs taken from women who smoke are less likely to be successfully fertilized.

If you want to start a family, you should quit smoking immediately. Besides affecting fertility, smoking during pregnancy can harm the fetus.

Q: What is the ovarian reserve and why is it important to someone trying to conceive?
A:

As more women delay pregnancy planning until their 30’s and beyond, the importance of studying their ovarian reserve of oocytes (eggs) becomes paramount. Women are born with a full complement of eggs in the ovaries, which reside in a resting pool until they are selected to move into a growing pool. Some of these eggs will become available for ovulation after menarche (a girl’s first menstruation cycle). This cycle of oocytes moving from the resting pool to the growing pool continues throughout the reproductive years until all of the eggs have been used (menopause). Menopause usually occurs around age 51.

An oocyte that leaves the resting pool takes about 220 days to participate in the ovulation process. When a woman’s age is advanced, problems can ensue because there aren’t as many ooctyes available for ovulation in each menstrual cycle. As these numbers decrease, the ovaries’ ability to produce normal eggs to undergo fertilization also is lowered (the ovarian reserve).

There are several tests that measure the ovarian reserve. One of them, the clomiphene citrate challenge test (CCCT) has been standardized and is widely accepted. For five days the patient takes 100 mg of clomiphene citrate (CC). Here FSH serum level is measured both before the test and after the five-day round of medication is completed. A decision about the ovarian reserve is made based on the levels of FSH.

Recently, other tests have been used to determine the ovarian reserve, but they have not become standardized or widely accepted. Measuring inhibin B, a hormone produced from the growing follicle that increases as the follicle and egg mature, for example, can be advantageous in certain cases. Since its levels vary less from cycle to cycle in comparison to FSH, inhibin B can be used to predict the ovarian reserve after stimulating the ovaries with gonadotropins. Ovarian volume and early follicle count are other methods undergoing further evaluation and study.

A major problem may occur if a woman wants to conceive and happens to have high levels of FSH early in any of her cycles. In some cases the problem cannot be resolved with any treatment, while in other cases it can be easily resolved. Therefore, any woman who has a single elevated FSH level should immediately undero further evaluation, and specific studies of treatment should be implemented in order to achieve her desired goal of conception.

Q: What is hemachromatosis? Can it cause infertility?
A:

Hemachromatosis is an inherited disorder affecting body chemistry in which the level of iron in the blood is too high. If left undetected and untreated, the condition can lead to health problems, such as cirrhosis of the liver, diabetes, and heart disorders.

More common in men than women, hemachromatosis can cause infertility. Common symptoms in men include difficulty in ejaculating, shrinking of the testes, loss of interest in sex, limited facial hair growth, and reduction in their sense of smell. These symptoms usually do not appear until age 40, but excessive alcohol drinkers may experience symptoms earlier because alcohol increases the amount of iron that is absorbed by the intestines. In women, it may cause amenorrhea (the absence or suppression of menstruation).

The condition is usually diagnosed with a blood test, and treatment is targeted at removing some of the excess iron from the body. About 1 pint of blood is removed each week until the iron levels return to normal levels. People with this condition should not drink alcohol or eat iron-rich foods.

Despite its frequency (affecting 3 in 1,000 people in the U.S.) and effect on the endocrine system, hemochromatosis is given little attention in endocrinology and infertility textbooks. This is certainly a disorder that should be considered when taking case histories.

Q: My sister just had an ectopic pregnancy and is worried that she won’t be able to conceive again. Can an ectopic pregnancy cause infertility?
A:

Occurring in about 1 in 100 pregnancies, an ectopic pregnancy is a pregnancy that implants outside the uterus, usually in a fallopian tube. If the condition is not detected and treated early, the pregnancy will continue to grow in the tube and the tube will eventually burst. If this happens, the tube will no longer be able to carry fertilized eggs on their way to the uterus in future conceptions. If the tube ruptures and is not immediately treated, the mother’s life also could be threatened.

Symptoms of an ectopic pregnancy include brown vaginal spotting or light bleeding accompanied by diffuse abdominal pelvic pain on one side or shoulder pain, and lightheadedness or fainting spells.

The good news is that new techniques for early diagnosis and treatment of ectopic (tubal) pregnancy have removed most of the risk for the mother and also have improved her chances of remaining fertile.

Besides high-resolution ultrasound to visualize the uterus and early gestational sac development, detection of the condition also is made through highly sensitive pregnancy tests that track the level of the hCG hormone in the mother’s blood. If the hormone level does not rise appropriately but still rises as the pregnancy progresses, an ectopic pregnancy may be suspected.

Transvaginal sonography is at the forefront for treating patients with a possible ectopic pregnancy. When the BhCG reaches around 2000 in a normal developing pregnancy, a small gestational sac should be visualized within the uterus. Between five to six weeks gestation, a yolk sac (visualized as a small, bright ring) should be seen within the gestational sac. If the BhCG is elevated enough to expect an intrauterine gestational sac, and one is not seen, an ectopic pregnancy is suspected.

Sometimes in the case of ectopic pregnancy, a small collection of fluid accumulates within the endometrial cavity (psuedosac). If the patient experiences pain, it may be due to a ruptured tube and fluid in the free spaces behind the uterus or around the liver and kidneys. Color doppler sonography can add information for further analysis. This technique utilizes color flow mapping to visualize increased blood flow to a suspicious area in the region of the fallopian tubes. A developing pregnancy outside of the uterus will demonstrate an increase in blood flow due to early placental tissue implanting in the fallopian tube. With transvaginal sonography a patient can be diagnosed earlier with an ectopic pregnancy and can be given the proper treatment in order to safeguard her ability to conceive again.

Laparoscopic surgery to remove the abnormal pregnancy is now routinely done. Less invasive than regular surgery, laparoscopic surgery also gives patients shorter hospital stays and quicker recoveries. But surgery is not the only route to take. If an ectopic pregnancy is diagnosed early enough, oral doses of the drug methotrexate can successfully treat the condition without the need for surgery.

If you have any questions regarding transvaginal sonography, please call Laurie Miller, DVIFG’s sonographer, at (856) 988-0072.

Q: Since I’ve been taking fertility drugs, I’ve been crying often. Are my hormones out of whack or it is just the uncertainty of infertility?
A:

Hormonal fluctuations are a normal part of the reproductive cycle in the human female. When you add fertility drugs to the mixture, some, but not all, women may experience strong emotions and mood swings. Should these swings become disabling in their intensity or frequency, medications and/or psychotherapy are available to “cut the edge.” Oftentimes “forewarned is forearmed” and not being taken by surprise can be of great support in going through this period of time. Knowing that it is a temporary phenomenon and oriented toward achieving the goal of having a baby will greatly aid a patient in retaining her perspective. A knowledgeable and supportive partner may also play a critical role.

The Delaware Valley Institute of Fertility & Genetics (DVIFG) can help you cope with the uncertainty of infertility. Through a unique program designed to help you discuss and work through your feelings and concerns, you will learn effective strategies to live each day to its fullest while trying to conceive.

Geoffrey D. Nusbaum, Ph..D., director of DVIFG’s Medical Psychotherapy and BioMedical Ethics Service, is uniquely qualified to help you cope while trying to conceive. A Fellow and Diplomate of the American Board of Medical Psychotherapy and a Fellow of the International Council of Sex Education and Parenthood at American University in Washington,DC. Dr. Nusbaum holds a clinical certificate from The American Association for Marriage and Family Therapy and is a Founding Member of the Mental Health Issues Section of the American Society for Reproductive Medicine. He has over 25 years of experience counseling people on how to deal with the stress associated with a medical condition, including infertility.

To make an appointment with Dr. Nusbaum, please call (856) 988-0072.

Q: Friends of ours recently joined a support group for infertile couples. Are they beneficial for everyone going through fertility treatments?
A:

Infertility support groups can often be a highly supportive milieu for a couple as they navigate their way through the maze of the infertility workup. It can be very helpful, supportive, and validating for a couple to see, hear, experience, and communicate with other couples that are on the same journey as they are. In some cases, issues may arise during the support group discussion that can then be addressed by the couple with or without professional support.

Like most other things in life, there is no “one-size-fits-all” solution, and each couple must determine if a support group can play a positive role in their infertility workup. Some couples may prefer a support group with only their peers, while others may be helped more by a support group led by a professional counselor.

The Delaware Valley Institute of Fertility & Genetics (DVIFG) can also help you cope with the uncertainty of infertility. Through a unique program designed to help you discuss and work through your feelings and concerns, you will learn effective strategies to live each day to its fullest while trying to conceive.

Geoffrey D. Nusbaum, Ph..D., director of DVIFG’s Medical Psychotherapy and BioMedical Ethics Service, is uniquely qualified to help you cope while trying to conceive. A Fellow and Diplomate of the American Board of Medical Psychotherapy and a Fellow of the International Council of Sex Education and Parenthood at American University in Washington,DC. Dr. Nusbaum holds a clinical certificate from The American Association for Marriage and Family Therapy and is a Founding Member of the Mental Health Issues Section of the American Society for Reproductive Medicine. He has over 25 years of experience counseling people on how to deal with the stress associated with a medical condition, including infertility.

To make an appointment with Dr. Nusbaum, please call (856) 988-0072.

Q: Can being a vegetarian affect my ability to conceive?
A:

Being on a vegetarian diet, regardless of whether or not you also eat dairy products, is actually healthier than regular diets containing meat products. In answer to your question regarding your ability to conceive, it’s not the vegetarian diet that causes problems but the reasons why you’re on it and how you take it that are more critical.

If a person goes on a vegetarian diet to lose weight and happily stays on it for weight control, then it’s unlikely to affect the reproductive system and fertility. On the other hand, if the vegetarian diet is difficult for her to follow and causes a lot of stress, then it will disrupt the reproductive system and create infertility problems.

From a physical point of view, if a woman loses too much weight while on a vegetarian diet and becomes underweight, then her reproductive system will be compromised or disrupted due to inadequate nutrition. This can lead to ovulatory dysfunction and infertility problems. On the other hand, if a woman consumes excess food, even on a vegetarian diet, and becomes overweight or obese, then she may develop a metabolic disorder such as insulin resistance, leading to ovulatory dysfunction and infertility.

Therefore, one cannot simply say that a vegetarian diet will affect infertility. It is why she is following this diet and where she stands as far as her mental and physical condition that will determine if this situation can affect her fertility.

If you plan to stay on a vegetarian diet, you should know that it lacks omega 3 fatty acids, important fatty acids that are essential to our health. They cannot be synthesized in our bodies, so they have to come from food intake, usually from fish or from some special plant such as flaxseed. Most vegetables do not have enough omega 3 fatty acids. Therefore, you may want to consider taking flaxseed oil capsules for omega 3 fatty acid supplementation, or fish oil. Ask your physician for advice on the proper amounts to take as supplements.

Q: I have been taking birth control pills for 10 years and now want to go off of them to try to start a family. How long do I have to wait before I can have unprotected intercourse? Also, can my long-term use of birth control pills affect my ability to conceive?
A:

You should wait at least three months after discontinuing the use of birth control pills before trying to conceive. This will give the body sufficient time to clear the estrogens and progestins present in the oral contraceptives and to enable the hypothalamus-hypophyseal-gonal axis to generate a healthy follicle/oocyte for a pregnancy to be achieved. Even in cases where women have unprotected intercourse soon after discontinuing birth control pills, conception has occurred. Studies indicate that oral contraceptive use does not affect the ability to conceive.

Pregnancy, however, does become more difficult to achieve as women age. In general, the later women try to conceive, the harder it is to become pregnant.

The benefits of taking oral contraceptives at an early age is that they may help prevent endometriosis, a common cause of infertility that occurs when tissue fragments of the endometrium (the innermost lining of the uterus) grow outside the uterus, causing scarring on the ovaries and the fallopian tubes. They also may offer some protection against sexually transmitted diseases, and lower a woman’s risk of developing certain types of cancer.

Q: Is the stress associated with the infertility workup sometimes associated with preterm labor?
A:

According to Geoffrey D. Nusbaum, Ph.D., director of DVIFG’s Medical Psychotherapy and BioMedical Ethics Service, there are numerous clinical studies indicating that reducing stress and anxiety through supportive intervention, such as counseling or stress management programs, can often prevent or stop preterm labor.

The important thing to remember is that you can control your attitudinal response to the stress of infertility. For help in coping with the stresses involved with infertility, call Dr. Nusbaum at (856) 988-0056.

Q: I am about 25 pounds overweight and trying to conceive. I understand that my excess weight can make conceiving more difficult. I’m concerned about going on a diet, however, because I want to eat nutritiously in case I do conceive. I’ve heard that a medical nutrition therapist can help me. Do you think I should visit one?
A:

You’re correct about wanting to lose weight in order to conceive. Infertility problems and weight go hand in hand. Research has found that obese women are two times more likely to be infertile than women of healthy weight.This is due to having too much insulin in the body resulting in a condition called “Syndrome X.”

Syndrome X can not only impede a woman’s ability to become pregnant, but her ability to carry to term as well. The good news is that with the help of a board certified Medical Nutrition Therapist, you can lose the weight and keep it off.

A professional who practices medical nutrition therapy is a crucial part of the infertility treatment team. A medical nutrition therapist can help you and your family understand why eating particular foods are crucial to good health and how to follow a sensible diet/exercise regimen to achieve a healthy weight. A medical nutritional therapist understands that these changes take time and develops gradual plans for changing food intake patterns. The goal of medical nutrition therapy is:

• to help you separate food and weight-related behaviors from psychological issues.

• to develop an action plan for changing food intake patterns.

• to create a life-long sensible diet/exercise program for maintaining a healthy weight.

• to promote overall good health to increase your chance of conceiving, to enhance self-esteem, and to improve metabolic control.

• to help couples make behavioral changes and to utilize support and referral sources to keep them on track.

At DVIFG we offer medical nutrition therapy with a registered dietitian and Certified Diabetes Educator in charge of the service. Melissa Bennett received her B.S. degree in Dietetics from the University of Delaware and has over a decade of experience as a clinical dietitian and educator. Besides individualized counseling, Ms. Bennett can provide you with educational literature on nutrition, personalized meal planning, exercise tips that really work, and easy low-fat cooking tips.

To make an appointment with Ms. Bennett, DVIFG’s Medical Nutrition Therapist, please call (856) 988-0072.

Q: Is there an emerging medical consensus on the possible use of cloning as a useful tool in helping the infertile couple to become parents?
A:

The biomedical ethics community is still divided on both the safety and ethical aspects of this emerging technology. At this point in time the Ethics Committee of the American Society of Reproductive Medicine (ASRM) has stated in its journal, Fertility and Sterility: “As long as the safety of reproductive SCNT [cloning] is uncertain, ethical issues have been insufficiently explored, and infertile couples have alternatives for conception, the use of reproductive SCNT by medical professionals does not meet standards of ethical accredibility.”

Q: Is it true that mountain biking can affect a man’s fertility?
A:

The jury is still out on this one, but a recent study conducted by Australian researchers found that the shocks and vibrations from the activity may cause physical damage and compromise men’s fertility. The scientists found that pressure from the bicycle seat can damage blood vessels and nerves in and around the scrotum. Since mountain biking often involves riding over rough terrain, the shocks to the groin only compound any preexisting problem.

More studies need to be conducted to determine whether frequent mountain biking can reduce sperm count. In the meantime, the study researchers suggest that male mountain bikers pad both the bike seat and their shorts and visit a bike shop to ensure that the seat is positioned high enough and at the proper angle.

The study did not mention the impact of mountain biking on female fertility. It did, however, mention that many activities done in excess can damage a man’s fertility, including cigarette smoking and beer drinking. Until more studies are performed, the safest route for men to follow is to mountain bike and exercise in other ways in moderation.

Q: I understand that if my husband and I begin fertility treatments, we will have to undergo genetic counseling. Is this necessary?
A:

Depending upon your reproductive history and other medical factors, you and your husband may benefit from preconceptional counseling and/or preimplantation genetic testing.

Preconceptional counseling is recommended in cases where couples have suffered early pregnancy loss, preterm labor, or other reproductive problems or where there’s a family history of certain genetic diseases. By screening couples for these genetic diseases before they conceive, it can help them understand the risks and plan accordingly.

Carrier screening can detect certain genetic diseases, including alpha- Thalassemia, beta-Thalassemia (a type of anemia affecting the production of hemoglobin), cystic fibrosis (a condition that affects all of the fluid- and mucus-secreting glands in the body and this leads to thick, abnormal secretions, especially in the lungs and pancreas), Sickle cell disease (a type of anemia usually affecting African Americans in which red blood cells become sickle shaped), Tay-Sachs disease (a fatal childhood disorder in which harmful chemicals accumulate in the brain that is most common in the Ashkenazi Jewish population), and many others.

Preimplantation genetic testing helps couples that choose IVF have a successful pregnancy. This new testing can identify genetic defects at two different stages, in an ovum (unfertilized egg) before fertilization or in an embryo (before implantation). Since approximately 60 percent of all reproductive losses in pregnancy are linked to a chromosomal abnormality, performing this testing may help prevent unsuccessful IVF pregnancies. In fact, a recent study found the pregnancy rate with IVF patients ages 35 to 45 increased from 16 to 30 percent when preimplantation genetic testing was conducted.

Besides screening for the same genetic conditions as preconceptional testing, preimplantation testing can detect certain gender-linked chromosomal disorders, Huntington’s disease (a brain disorder that causes personality changes, involuntary movements, and dementia), Lesch-Nyhan syndrome (a metabolic disease that affects only males, in whom mental retardation, aggressive behavior, self-mutilation, and renal failure are exhibited), muscular dystrophy (a group of genetic conditions in which muscles become weak and wasted), Hemophilia A (a blood disorder), and Retinitis pigmentosa (a progressive disease in which the retina progressively degenerates).

Q: My husband and I have been told that we’re excellent candidates for in vitro fertilization (IVF). What is IVF?
A:

In vitro fertilization (IVF) is a type of assisted conception that involves mixing eggs and sperm outside the body.

IVF offers a chance at parenthood to infertile couples where women have blocked or absent fallopian tubes, where men have low sperm counts, and where other infertility problems occur.

In IVF, eggs are surgically removed from the ovary and mixed with sperm outside the body in a petri dish. After about 40 hours, the eggs are examined to see if they have become fertilized by the sperm and are dividing into cells. These fertilized eggs (embryos) are then placed in the woman’s uterus. (IVF makes it possible for couples to conceive without the use of the fallopian tubes.) The overall success rate of IVF is approximately 21 percent.

Q: I have been taking my prenatal vitamins, exercising regularly, and cutting down on stress in order to enhance my chances of conceiving. Is there anything that my husband should be doing to enhance our chances?
A:

The overall health of both partners has an important effect on fertility. Like you, he should eat a healthy diet, exercise regularly, and find ways to reduce stress. He should also not wear tight underwear, avoid hot baths, saunas, and hot tubs, and limit his exposure to hydrocarbons and other chemicals in the workplace because these factors can affect sperm quality.

He should also reconsider taking the following prescription drugs due to their association with infertility in men: cimetidine (Tagament®), nitrofurantoin (an antibiotic), sulfasalazine (a drug used to reduce inflammation of the intestines), spironolactone (a potassium-sparing diuretic drug), and calcium channel blockers (such as nifedipine®). If he smokes, he should quit immediately. Secondhand smoke can affect your fertility as well.

You should also make sure that your husband is getting enough folic acid in his diet. A recent study conducted by scientists at the University of California, Berkeley and the Western Human Nutrition Research Center (WHNRC) in Davis published in the February 2001 issue of Fertility and Sterility, found that low levels of folic acid in men are associated with decreased sperm count and decreased sperm density. Good dietary sources of folic acid include fortified breakfast cereals, leafy greens, legumes and orange juice.

The researchers now plan to study the effect of too little amounts of other vitamins on male reproductive health. The scientists found in a previous study conducted in 1991 that men with low levels of vitamin C had more genetic damage in their sperm and that smokers were at even greater risk.

Men trying to help their partner conceive may also want to steer clear of St. John’s wort, echinacea, and gingkgo biloba, three popular herbs on the market. According to a preliminary study published in Fertility and Sterility, all three of these herbs affected sperm in some way. The researchers found that the herbs made it more difficult or impossible for the sperm to penetrate eggs and/or changed the sperm’s genetic makeup, making them less viable.

Since heavy alcohol consumption has been found to reduce sperm count, he should drink no more than two alcoholic drinks occasionally. You should also have frequent intercourse (several times per week) to boost your chances of conceiving.

After adopting these healthy lifestyle changes, you should be able to conceive after six months to one year of trying. If you aren’t successful after that period of time, ask your physician for a referral to a physician specializing in infertility. For most couples, it’s only a matter of time before they achieve pregnancy. In fact, 80 percent of couples are successful within six to eight months. Good luck!

Q: What are the major reasons that infertility problems rise with age?
A:

Although many women over age 35 have little difficulty conceiving a child, age is a factor in fertility. The older a woman gets, the greater her chance of miscarriage. Fertility problems, however, usually don’t seriously develop until a woman reaches age 40, although women in their mid to late 30s may have problems conceiving due to a natural decline in ovarian function. Although men experience a decrease in sperm production after age 25, some men remain fertile into their 60s and even their 70s. Due to the fact that more and more couples are delaying starting a family until their 30s or beyond, infertility is becoming more common. That’s why in women over 35, a fertility evaluation should be given after six months of unprotected intercourse.

Other factors regarding age and infertility include:

• A decreased ovarian reserve suggests a poor prognosis for fertility.

• Older women hoping to conceive may need aggressive treatment to capitalize on the “window of infertility.”

• Egg donation is usually the best option for women over 40 who have elevated basal FSH (follicle-stimulating hormone) levels.

Q: I just learned that I have low levels of FSH (follicle-stimulating hormone). Can it be treated so that I can have the baby I always wanted?
A:

Yes, there is, and treatment will be based on your diagnosis. If tests have shown that you are not ovulating due to low levels of FSH, drugs will probably be prescribed to stimulate ovulation. These drugs are used when the inability to conceive results from a hormonal imbalance in either the male or the female. Fertility is influenced by hormones produced in the brain by the hypothalamus and the pituitary gland. The hypothalamus produces gonadotropin-releasing hormone, which regulates the release of gonadotropin hormones from the pituitary