Reseveratrol and PCO

Resveratrol, a natural chemical present in grapes, nuts and berries, is known to have antioxidant, anti-inflammatory and cardio protective properties. It was also found to have a beneficial effect in PCO by reducing the production of androgens approximately by 25%. Both ovarian and adrenal productions of male hormones were decreased to the same degree and in addition there was a decrease in fasting insulin level by 30% and increase in the Insulin Sensitivity Index by 2/3.

Resveratrol, the chemical name is trans-3,5,4′-trihydroxystilbene, seems to combine the properties of two treatment approaches in common use for the treatment of PCO in women, that of anti androgen and of metabolic derangement. Spironolactone, flutamide is prescribed to combat the effect of high levels of androgens in the peripheral, acne, and hirsutism and oral contraceptives to decrease the androgen production at the ovaries. Although effective clinically are not acceptable during the treatment of infertility. Another medication, Cyproterone acetate is not available in the US. Metformin is also routinely prescribed for patients that have PCO and attempt pregnancy, in the hope that will improve any metabolic arrangement. Resveratrol exerts its effect by inhibiting the key rate limiting enzyme in androgen production, 17a-hydroxylase at DVIF&G.

At DVIF&G patients with PCO undergo an evaluation to assess the underlying cause of their ovulatory disorder and subsequently receive treatment to correct it. One third of the patients become pregnant on their own and the remaining require mild measures to achieve the same results. This approach has achieved not only the goal of having a family but at the same time addressing an underlying medical issue, thus safeguarding a safe pregnancy and a healthy child.

Resveratrol (trans-resveratrol; 3,5,4′-trihydroxystilbene)

total testosterone 23.1%
dehydroepiandrosterone sulfate (DHEAS) 22.2%
fasting insulin 31.8%
Insulin Sensitivity Index 66.3%